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KMID : 0043320080310010009
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Archives of Pharmacal Research
2008 Volume.31 No. 1 p.9 ~ p.0
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Application of Coupling Reaction between Lithiated Toluamide and Benzonitrile for the Synthesis of Phenolic Benzo[c]phenanthridine Alkaloid, Oxyterihanine
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Le Thanh Nguyen
Myvan Hue-Thi
Lee Suh-Hee
Choi Hyun-Jin
Lee Kwang-Youl
Kang Bok-Yun
Cho Won-Jea
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Abstract
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The total synthesis of the natural phenolic benzo[c]phenanthridine alkaloid, oxyterihanine, was accomplished via substituted 3-arylisoquinoline intermediate. The key reaction was a coupling between the o-toluamide 4 and the benzonitrile 5.
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KEYWORD
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Phenolic benzo[c]phenanthridine, 3-Arylisoquinoline, Oxyterihanine, Cycloaddition, Natural alkaoid
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